Neuroinflammation in suicide: Toward a comprehensive model
Identifieur interne : 000B20 ( Main/Exploration ); précédent : 000B19; suivant : 000B21Neuroinflammation in suicide: Toward a comprehensive model
Auteurs : Philippe Courtet [France] ; Lucas Giner [Espagne] ; Maude Sénèque [France] ; Sébastien Guillaume [France] ; Emilie Olié [France] ; Deborah Ducasse [France]Source :
- World Journal of Biological Psychiatry [ 1562-2975 ] ; 2016-12.
English descriptors
Abstract
OBJECTIVES:Suicidal behaviour (SB) entered the DSM-5, underlying a specific biological vulnerability. Then, recent findings suggested a possible role of the immune system in SB pathogenesis. The objective of this review is to present these main immune factors involved in SB pathogenesis.METHODS:We conducted a review using Preferred Reporting Items for Systematic reviews and Meta-Analysis criteria, and combined ("Inflammation") AND ("Suicidal ideation" OR "Suicidal attempt" OR "suicide").RESULTS:Post mortem studies demonstrated associations between suicide and inflammatory cytokines in the orbitofrontal cortex, a brain region involved in suicidal vulnerability. Also, microgliosis and monocyte-macrophage system activation may be a useful marker of suicide neurobiology. Kynurenine may influence inflammatory processes, and related molecular pathways may be involved in SB pathophysiology. Few recent studies associated inflammatory markers with suicidal vulnerability: serotonin dysfunction, impulsivity and childhood trauma. Interestingly, the perception of threat that leads suicidal individuals to contemplate suicide may activate biological stress responses, including inflammatory responses.CONCLUSIONS:Translational projects would be crucial to identify a specific marker in SB disorders, to investigate its clinical correlations, and the interaction between inflammatory cytokines and monoamine systems in SB. These researches might lead to new biomarkers and novel directions for therapeutic strategies.
Url:
DOI: 10.3109/15622975.2015.1054879
Affiliations:
- Espagne, France
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
- PRES Sud de France, Université Montpellier 1
Links toward previous steps (curation, corpus...)
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- to stream Hal, to step Curation: 000091
- to stream Hal, to step Checkpoint: 000072
- to stream Main, to step Merge: 000B21
- to stream Main, to step Curation: 000B20
Le document en format XML
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<author><name sortKey="Guillaume, Sebastien" sort="Guillaume, Sebastien" uniqKey="Guillaume S" first="Sébastien" last="Guillaume">Sébastien Guillaume</name>
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<orgName>Université de Montpellier</orgName>
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<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
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<orgName type="university">Université Montpellier 1</orgName>
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<author><name sortKey="Olie, Emilie" sort="Olie, Emilie" uniqKey="Olie E" first="Emilie" last="Olié">Emilie Olié</name>
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<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
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<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
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<author><name sortKey="Ducasse, Deborah" sort="Ducasse, Deborah" uniqKey="Ducasse D" first="Deborah" last="Ducasse">Deborah Ducasse</name>
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<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
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<orgName>Université de Montpellier</orgName>
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<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
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<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
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</analytic>
<idno type="DOI">10.3109/15622975.2015.1054879</idno>
<series><title level="j">World Journal of Biological Psychiatry</title>
<idno type="ISSN">1562-2975</idno>
<imprint><date type="datePub">2016-12</date>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>biomarker</term>
<term>inflammation</term>
<term>microglia</term>
<term>social ties</term>
<term>suicidal behaviour</term>
</keywords>
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<front><div type="abstract" xml:lang="en"> <p>OBJECTIVES:Suicidal behaviour (SB) entered the DSM-5, underlying a specific biological vulnerability. Then, recent findings suggested a possible role of the immune system in SB pathogenesis. The objective of this review is to present these main immune factors involved in SB pathogenesis.METHODS:We conducted a review using Preferred Reporting Items for Systematic reviews and Meta-Analysis criteria, and combined ("Inflammation") AND ("Suicidal ideation" OR "Suicidal attempt" OR "suicide").RESULTS:Post mortem studies demonstrated associations between suicide and inflammatory cytokines in the orbitofrontal cortex, a brain region involved in suicidal vulnerability. Also, microgliosis and monocyte-macrophage system activation may be a useful marker of suicide neurobiology. Kynurenine may influence inflammatory processes, and related molecular pathways may be involved in SB pathophysiology. Few recent studies associated inflammatory markers with suicidal vulnerability: serotonin dysfunction, impulsivity and childhood trauma. Interestingly, the perception of threat that leads suicidal individuals to contemplate suicide may activate biological stress responses, including inflammatory responses.CONCLUSIONS:Translational projects would be crucial to identify a specific marker in SB disorders, to investigate its clinical correlations, and the interaction between inflammatory cytokines and monoamine systems in SB. These researches might lead to new biomarkers and novel directions for therapeutic strategies.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>France</li>
</country>
<region><li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Montpellier</li>
</settlement>
<orgName><li>PRES Sud de France</li>
<li>Université Montpellier 1</li>
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</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name>
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<name sortKey="Ducasse, Deborah" sort="Ducasse, Deborah" uniqKey="Ducasse D" first="Deborah" last="Ducasse">Deborah Ducasse</name>
<name sortKey="Guillaume, Sebastien" sort="Guillaume, Sebastien" uniqKey="Guillaume S" first="Sébastien" last="Guillaume">Sébastien Guillaume</name>
<name sortKey="Olie, Emilie" sort="Olie, Emilie" uniqKey="Olie E" first="Emilie" last="Olié">Emilie Olié</name>
<name sortKey="Seneque, Maude" sort="Seneque, Maude" uniqKey="Seneque M" first="Maude" last="Sénèque">Maude Sénèque</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Giner, Lucas" sort="Giner, Lucas" uniqKey="Giner L" first="Lucas" last="Giner">Lucas Giner</name>
</noRegion>
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